Hormones acts on kidney

A. Aldosterone

·        Increase NaCl and H₂O reabsorbtion

·        Increase K⁺ excreation

·        Increase proton excretion

B. ADH

·        Increase water reabsorption from DCT and CD by making them permeable to H₂O

·        Vasoconstriction

·        Potentiate the pressor effects of catecholamines

C. ANP

·        Decreased NaCl and water reabsorption from CD

·        Antagonizes sympathetic nervous system activity

·        Antagonizes renin-angiotensin-aldosterone system

·        Increase GFR by dilatation of afferent arteriole

·        Inhibits ADH release

D. Angiotensin II

·        Increases NaCl and water reabsorption from PCT

·        Increase aldosterone secretion from adrenal cortex to increase NaCl and water reabsorption from DCT and CD

·        Causes constriction of efferent arteriole at physiological concentration but at high concentration it causes constriction of both afferent and efferent arterioles and reduces RBF and GFR

·        Enhances ADH release and stimulates thirst center

·        Generalized vasoconstriction

E. Dopamine

·        Increases RBF and decreases NaCl reabsorption from PCT

·        Causes natriuresis and diuresis

F.  PTH

·        Increase calcium reabsorption from PCT

·        Decreases phosphate reabsorption from PCT

G. Prostaglandin

·        Regulates renal hemodynamics and maintains RBF and GFR

·        Antagonizes SNS activity, ADH and angeotensin-II

·        Net effect is renal vasodilatation, natriuresis and diuresis

H. Catecholamine

·        Renal vasoconstriction

·        Stimulation of RAAS and increases rennin secretion

·        Renal NaCl and H_2­O retention