What is hyperspleenism?

Def: Hyperspleenism is a clinical syndrome that can be seen in any form of spleenomegaly. It is characterized by

1. Enlargement of the spleen.
2. Reduction of at least one cell line in the blood, in the presence of normal bone marrow function.
3. Evidence of increased release of premature cells such as reticulocytes or immature platelets, from the bone marrow into the blood.