Granulation tissue is characterized by proliferation of fibroblasts and new thin-walled, delicate capillaries in a loose extracellular matrix, often with admixed inflammatory cells, mainly macrophages. This tissue progressively invades the site of injury; the amount of granulation tissue that is formed depends on the size of the tissue deficit created by the wound and the intensity of inflammation.
Friday, July 9, 2021
Friday, July 2, 2021
What is repair by scar formation? What are the steps?
If repair cannot be accomplished by regeneration alone, it occurs by replacement of the injured cells with connective tissue, leading to the formation of a scar, or by a combination of regeneration of some residual cells and scar formation.
Steps involved in repair in scar formation:
- Clot formation
- Inflammation
- Angiogenesis and formation of granulation tissue,
- Migration and proliferation of fibroblasts,
- Collagen synthesis,
- Connective tissue remodeling.
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