Mechanism of Increased Vascular Permeability in Acute Inflammation

Several mechanisms involved in increased vascular permeability in acute inflammation:

1. Contraction of endothelial cells resulting in increased interendothelial spaces is the most common mechanism of vascular leakage.
2. Endothelial injury, resulting in endothelial cell necrosis and detachment.
3. Increased transport of fluids and proteins, called transcytosis, through the endothelial cell. This process may involve intracellular channels that may be stimulated by certain factors, such as vascular endothelial growth factor (VEGF), that promote vascular leakage.