Nerve supply of blood vessel

Most blood vessels that contain smooth muscle in their walls are supplied with a profuse network of unmyelinated sympathetic nerve fibers whose neurotransmitter in norepinephrine. Discharge of norepinephrine from these nerve endings results in vasoconstriction. Because these efferent nerve generally do not enter the media of arteries the neurotransmitter must diffuse for several micrometers to effect smooth muscle cells of the media.
Arteries of skeletal muscle also receive a cholinergic vasodialator nerve supply.